10:18 Prioritize sleep for overall health, $60M TAME trial tests metformin's effects on aging, animal kingdom's phenotypes challenge entropy theory, advancements in biology lead to new treatments, but understanding the brain is the final frontier for longevity.
- The speaker recommends prioritizing sleep over dietary changes for overall health, and questions the common belief that feeling better equates to better health.
- The TAME trial is a $60 million study testing the effects of the diabetes drug metformin on aging biomarkers in humans, motivated by retrospective findings that those who took the drug had better health spans and less age-related disease.
- The diversity of phenotypes in the animal kingdom and the differences in longevity between naked mole rats and rats challenge the theory of entropy and offer opportunities for learning from other animals.
- Advancements in biology, such as the use of proteins, viruses, genetic engineering, and stem cells, are leading to new treatments for diseases, but the final frontier is understanding the brain.
- It is possible to impact lifespan between three months to ten years, but none of the current tools will be sufficient on their own to result in an engineered lifespan.
- Investing in tooling is crucial for impacting longevity, but there is still uncertainty about achieving unbounded engineered ability to do so.